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Harrison's Principles of Internal Medicine, 18e | Part 16. Endocrinology and Metabolism > Section 1. Endocrinology > | Chapter 348. The Menopause Transition and Postmenopausal Hormone Therapy Sections: The Menopause Transition and Postmenopausal Hormone Therapy: Introduction, Perimenopause, Menopause and Postmenopausal Hormone Therapy, Further Readings. Topics Discussed: hormone replacement therapy; menopause; perimenopause. Excerpt:"Menopause is the permanent cessation of menstruation due to loss of ovarian follicular function. It is diagnosed retrospectively after 12 months of amenorrhea. The average age at menopause is 51 years among U.S. women. Perimenopause refers to the time period preceding menopause, when fertility wanes and menstrual cycle irregularity increases, until the first year after cessation of menses. The onset of perimenopause precedes the final menses by 2 to 8 years, with a mean duration of four years. Smoking accelerates the menopausal transition by 2 years...."
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