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Harrison's Principles of Internal Medicine, 18e
| Part 16. Endocrinology and Metabolism > Section 2. Disorders of Bone and Mineral Metabolism > |
Chapter 352. Bone and Mineral Metabolism in Health and Disease
Sections: Bone Structure and Metabolism, Calcium Metabolism, Phosphorus Metabolism, Magnesium Metabolism, Vitamin D, Further Readings.
Topics Discussed: bone and bones; bone mineral homeostasis.
Excerpt:"Bone is a dynamic tissue that is remodeled constantly throughout life. The arrangement of compact and cancellous bone provides strength and density suitable for both mobility and protection. In addition, bone provides a reservoir for calcium, magnesium, phosphorus, sodium, and other ions necessary for homeostatic functions. Bone also hosts and regulates hematopoiesis by providing niches for hematopoietic cell proliferation and differentiation. The skeleton is highly vascular and receives about 10% of the cardiac output. Remodeling of bone is accomplished by two distinct cell types: osteoblasts produce bone matrix, and osteoclasts resorb the matrix...."
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