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Harrison's Principles of Internal Medicine, 18e
| Part 17. Neurologic Disorders > Section 2. Diseases of the Central Nervous System > |
Chapter 379. Primary and Metastatic Tumors of the Nervous System
Sections: Introduction, Approach to the Patient: Primary and Metastatic Tumors of the Nervous System, Primary Brain Tumors, Intrinsic "Malignant" Tumors, Extrinsic "Benign" Tumors, Other Benign Tumors, Neurocutaneous Syndromes (Phakomatoses), Tumors Metastatic to the Brain, Leptomeningeal Metastases, Epidural Metastasis, Neurologic Toxicity of Therapy, Toxicity from Chemotherapy, Further Readings.
Topics Discussed: central nervous system tumor.
Excerpt:"Primary brain tumors are diagnosed in approximately 52,000 people each year in the United States. At least one-half of these tumors are malignant and associated with a high mortality rate. Glial tumors account for about 60% of all primary brain tumors, and 80% of those are malignant neoplasms. Meningiomas account for 25%, vestibular schwannomas 10%, and central nervous system (CNS) lymphomas about 2%. Brain metastases are three times more common than all primary brain tumors combined and are diagnosed in approximately 150,000 people each year. Metastases to the leptomeninges and epidural space of the spinal cord each occur in approximately 3–5% of patients with systemic cancer and are also a major cause of neurologic disability in this population...."
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