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Harrison's Principles of Internal Medicine, 18e
| Part 17. Neurologic Disorders > Section 3. Nerve and Muscle Disorders > |
Chapter 388. Polymyositis, Dermatomyositis, and Inclusion Body Myositis
Sections: Polymyositis, Dermatomyositis, and Inclusion Body Myositis: Introduction, Further Readings.
Topics Discussed: dermatomyositis; idiopathic inflammatory myopathy; myositis, inclusion body; polymyositis.
Excerpt:"The inflammatory myopathies represent the largest group of acquired and potentially treatable causes of skeletal muscle weakness. They are classified into three major groups: polymyositis (PM), dermatomyositis (DM), and inclusion body myositis (IBM).The prevalence of the inflammatory myopathies is estimated at 1 in 100,000. PM as a stand-alone entity is a rare disease. DM affects both children and adults and women more often than men. IBM is three times more frequent in men than in women, more common in whites than blacks, and is most likely to affect persons aged >50 years.The actual onset of PM is often not easily determined, and patients typically delay seeking medical advice for several weeks or even months. This is in contrast to DM, in which the rash facilitates early recognition (see below). PM mimics many other myopathies and is a diagnosis of exclusion. It is a subacute inflammatory myopathy affecting adults, and rarely children, who do not have any of the following: rash, involvement of the extraocular and facial muscles, family history of a neuromuscular disease, history of exposure to myotoxic drugs or toxins, endocrinopathy, neurogenic disease, muscular dystrophy, biochemical muscle disorder (deficiency of a muscle enzyme),..."
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