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Harrison's Principles of Internal Medicine, 18e | Part 17. Neurologic Disorders > Section 6. Alcoholism and Drug Dependency > | Chapter 395. Nicotine Addiction Sections: Nicotine Addiction: Introduction, Disease Manifestations of Cigarette Smoking, Pharmacologic Interactions, Other Forms of Tobacco Use, Lower Tar and Nicotine Cigarettes, Cessation, Physician Intervention (Table 395-3), Prevention, Further Readings. Topics Discussed: nicotine; nicotine dependence; smoking. Excerpt:"The use of tobacco leaf to create and satisfy nicotine addiction was introduced to Columbus by Native Americans and spread rapidly to Europe. Use of tobacco as cigarettes, however, only became popular in the twentieth century and so is a modern phenomenon, as is the epidemic of disease caused by this form of tobacco use...."
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