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Harrison's Principles of Internal Medicine, 18e
| Part 8. Infectious Diseases > Section 12. Infections Due to DNA Viruses > |
Chapter 182. Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Sections: Cytomegalovirus, Human Herpesvirus Types 6, 7, and 8, Further Readings.
Topics Discussed: cytomegalovirus infection.
Excerpt:"Cytomegalovirus (CMV), which was initially isolated from patients with congenital cytomegalic inclusion disease, is now recognized as an important pathogen in all age groups. In addition to inducing severe birth defects, CMV causes a wide spectrum of disorders in older children and adults, ranging from an asymptomatic subclinical infection to a mononucleosis syndrome in healthyindividuals to disseminated disease in immunocompromised patients. Human CMV is one of several related species-specific viruses that cause similar diseases in various animals. All are associated with the production of characteristic enlarged cells—hence the name cytomegalovirus.Fetal infections range from inapparent to severe and disseminated. Cytomegalic inclusion disease develops in  5% of infected fetuses and is seen almost exclusively in infants born to mothers who develop primary infections during pregnancy. Petechiae, hepatosplenomegaly, and jaundice are the most common presenting features (60–80% of cases). Microcephaly with or without cerebral calcifications, intrauterine growth retardation, and prematurity are reported in 30–50% of cases. Inguinal hernias and chorioretinitis are less common. Laboratory abnormalities include..."
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