AccessMedicine | Fitzpatrick's Dermatology in General Medicine, 7e

Fitzpatrick's Dermatology in General Medicine, 7e

Klaus Wolff, Lowell A. Goldsmith, Stephen I. Katz, Barbara A. Gilchrest, Amy S. Paller, David J. Leffell

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Part 1. Introduction

Section 1. General Considerations
Chapter 1	The Epidemiology and Burden of Skin Disease
Chapter 2	Evidence-Based Dermatology
Chapter 3	Public Health in Dermatology
Section 2. Approach to Dermatologic Diagnosis
Chapter 4	Structure of Skin Lesions and Fundamentals of Clinical Diagnosis
Chapter 5	Diagnostic Procedures and Devices
Chapter 6	Basic Pathologic Reactions of the Skin
Section 3. Overview of Biology, Development, and Structure of Skin
Chapter 7	Development and Structure of Skin
Chapter 8	Genetics in Relation to the Skin
Chapter 9	Basic Science Approaches to the Pathophysiology of Skin Disease

Part 2. Disorders Presenting in Skin and Mucous Membranes

Section 4. Inflammatory Disorders Based on T-Cell Reactivity and Dysregulation
Chapter 10	Innate and Adaptive Immunity in the Skin
Chapter 11	Cytokines
Chapter 12	Chemokines
Chapter 13	Allergic Contact Dermatitis
Chapter 14	Atopic Dermatitis (Atopic Eczema)
Chapter 15	Nummular Eczema and Lichen Simplex Chronicus/Prurigo Nodularis
Chapter 16	Vesicular Palmoplantar Eczema
Chapter 17	Autosensitization Dermatitis
Chapter 18	Psoriasis
Chapter 19	Psoriatic Arthritis
Chapter 20	Reactive Arthritis
Chapter 21	Pustular Eruptions of Palms and Soles
Chapter 22	Seborrheic Dermatitis
Chapter 23	Exfoliative Dermatitis
Chapter 24	Pityriasis Rubra Pilaris
Chapter 25	Parapsoriasis and Pityriasis Lichenoides
Chapter 26	Lichen Planus
Chapter 27	Lichen Nitidus
Chapter 28	Graft-versus-Host Disease
Chapter 29	Skin Disease in Acute and Chronic Immunosuppression
Section 5. Inflammatory Diseases Based on Neutrophils and Eosinophils
Chapter 30	Regulation of the Production and Activation of Neutrophils and Eosinophils
Chapter 31	Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome)
Chapter 32	Pyoderma Gangrenosum
Chapter 33	Granuloma Faciale
Chapter 34	Sub-Corneal Pustular Dermatosis (Sneddon-Wilkinson Disease)
Chapter 35	Eosinophils in Cutaneous Diseases
Section 6. Inflammatory Diseases Based on Abnormal Humoral Reactivity and Other Inflammatory Diseases
Chapter 36	Humoral Immunity and Complement
Chapter 37	Urticaria and Angioedema
Chapter 38	Erythema Multiforme
Chapter 39	Epidermal Necrolysis (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis)
Chapter 40	Cutaneous Reactions to Drugs
Chapter 41	Pityriasis Rosea
Chapter 42	Erythema Annulare Centrifugum and Other Figurate Erythemas
Chapter 43	Granuloma Annulare
Section 7. Disorders of Epidermal Differentiation and Keratinization
Chapter 44	Epidermal Growth and Differentiation
Chapter 45	Skin as an Organ of Protection
Chapter 46	Irritant Contact Dermatitis
Chapter 47	The Ichthyoses
Chapter 48	Inherited Keratodermas of Palms and Soles
Chapter 49	Acantholytic Disorders of the Skin: Darier-White Disease, Acrokeratosis Verruciformis, Grover Disease, and Hailey-Hailey Disease
Chapter 50	Porokeratosis
Section 8. Disorders of Epidermal and Dermal-Epidermal Cohesion and Vesicular and Bullous Disorders
Chapter 51	Epidermal and Epidermal-Dermal Cohesion
Chapter 52	Pemphigus
Chapter 53	Paraneoplastic Pemphigus
Chapter 54	Bullous Pemphigoid
Chapter 55	Cicatricial Pemphigoid
Chapter 56	Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood
Chapter 57	Pemphigoid Gestationis (Herpes Gestationis)
Chapter 58	Epidermolysis Bullosa Acquisita
Chapter 59	Dermatitis Herpetiformis
Chapter 60	Inherited Epidermolysis Bullosa
Section 9. Disorders of the Dermal Connective Tissue
Chapter 61	Collagen, Elastic Fibers, and Extracellular Matrix of the Dermis
Chapter 62	Morphea
Chapter 63	Lichen Sclerosus
Chapter 64	Dermal Hypertrophies
Chapter 65	Anetoderma and Other Atrophic Disorders of the Skin
Chapter 66	Constricting Bands (Ainhum and Pseudoainhum)
Chapter 67	Acquired Perforating Disorders
Section 10. Disorders of Subcutaneous Tissue
Chapter 68	Panniculitis
Chapter 69	Lipodystrophy
Section 11. Disorders of Melanocytes
Chapter 70	Biology of Melanocytes
Chapter 71	Albinism and Other Genetic Disorders of Pigmentation
Chapter 72	Vitiligo
Chapter 73	Hypomelanoses and Hypermelanoses
Section 12. Disorders of the Oral and Genital Integument
Chapter 74	Biology and Pathology of the Oral Cavity
Chapter 75	Diseases and Disorders of the Male Genitalia
Chapter 76	Diseases and Disorders of the Female Genitalia

Part 3. Disorders of the Skin Appendages

Section 13. Disorders of the Sebaceous Glands
Chapter 77	Biology of Sebaceous Glands
Chapter 78	Acne Vulgaris and Acneiform Eruptions
Chapter 79	Rosacea
Chapter 80	Perioral Dermatitis
Section 14. Disorders of the Eccrine and Apocrine Glands
Chapter 81	Biology of Eccrine, Apocrine, and Apoeccrine Sweat Glands
Chapter 82	Disorders of the Eccrine Sweat Glands and Sweating
Chapter 83	Disorders of the Apocrine Sweat Glands
Section 15. Disorders of the Hair and Nails
Chapter 84	Biology of Hair Follicles
Chapter 85	Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes
Chapter 86	Hair Growth Disorders
Chapter 87	Biology of Nails and Nail Disorders

Part 4. Disorders Due to the Environment

Section 16. Disorders Due to Ultraviolet Radiation
Chapter 88	Fundamentals of Cutaneous Photobiology and Photoimmunology
Chapter 89	Acute and Chronic Effects of Ultraviolet Radiation on the Skin
Chapter 90	Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photo-Exacerbated
Chapter 91	Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents
Section 17. Skin Changes Due to Other Physical and Chemical Factors
Chapter 92	Thermoregulation
Chapter 93	Cold Injuries
Chapter 94	Thermal Injuries
Chapter 95	Radiobiology and Radiation Effects
Chapter 96	Skin Problems in Amputees and Ostomates
Chapter 97	Corns and Calluses
Chapter 98	Sports Dermatology
Chapter 99	Decubitus (Pressure) Ulcers
Chapter 100	Body Art

Part 5. Neurocutaneous and Psychocutaneous Aspects of Skin Disease

Section 18. Neurocutaneous and Psychocutaneous Skin Disease
Chapter 101	Neurobiology of the Skin
Chapter 102	Pathophysiology and Clinical Aspects of Pruritus
Chapter 103	Psychocutaneous Diseases
Chapter 104	Cutaneous Manifestations of Drug Abuse
Chapter 105	Skin Signs of Physical Abuse

Part 6. Skin Changes across the Span of Life

Section 19. From Birth to Old Age
Chapter 106	Neonatal, Pediatric, and Adolescent Dermatology
Chapter 107	Skin Changes and Diseases in Pregnancy
Chapter 108	Aging of Skin

Part 7. Neoplasia

Section 20. Carcinogenesis
Chapter 109	Genome Instability, DNA Repair, and Cancer
Chapter 110	Carcinogenesis: Chemical
Chapter 111	Oncogenes, Tumor Suppressor Genes, and Viral Carcinogenesis
Chapter 112	Carcinogenesis: Ultraviolet Radiation
Section 21. Epidermal and Appendageal Tumors
Chapter 113	Epithelial Precancerous Lesions
Chapter 114	Squamous Cell Carcinoma
Chapter 115	Basal Cell Carcinoma
Chapter 116	Basal Cell Nevus Syndrome
Chapter 117	Keratoacanthoma
Chapter 118	Benign Epithelial Tumors, Hamartomas, and Hyperplasias
Chapter 119	Appendage Tumors and Hamartomas of the Skin
Chapter 120	Merkel Cell Carcinoma
Chapter 121	Mammary and Extramammary Paget Disease
Section 22. Melanocytic Tumors
Chapter 122	Benign Neoplasias and Hyperplasias of Melanocytes
Chapter 123	Atypical Melanocytic Nevi
Chapter 124	Cutaneous Melanoma
Section 23. Tumors and Hyperplasias of the Dermis and Subcutaneous Fat
Chapter 125	Malignant Fibrous Tumors of the Dermis
Chapter 126	Vascular Tumors
Chapter 127	Neoplasias and Hyperplasias of Muscular and Neural Origin
Chapter 128	Kaposi Sarcoma
Chapter 129	Neoplasms of Subcutaneous Fat

Part 8. The Skin in Systemic Disease

Section 24. Skin in Nutritional, Metabolic, and Heritable Disease
Chapter 130	Cutaneous Changes in Nutritional Disease
Chapter 131	Cutaneous Changes in Errors of Amino Acid Metabolism
Chapter 132	The Porphyrias
Chapter 133	Amyloidosis and the Skin
Chapter 134	Systemic Autoinflammatory Diseases
Chapter 135	Xanthomatoses and Lipoprotein Disorders
Chapter 136	Fabry Disease
Chapter 137	Lipoid Proteinosis
Chapter 138	Cutaneous Mineralization and Ossification
Chapter 139	Heritable Disorders of Connective Tissue with Skin Changes
Chapter 140	Hereditary Disorders of Genome Instability and DNA Repair
Chapter 141	Tuberous Sclerosis Complex
Chapter 142	The Neurofibromatoses
Chapter 143	Ectodermal Dysplasias
Chapter 144	Genetic Immunodeficiency Diseases
Section 25. Skin Manifestations of Bone Marrow or Blood Chemistry Disorders
Chapter 145	Hematologic Diseases
Chapter 146	Cutaneous Lymphoma
Chapter 147	Inflammatory Diseases that Simulate Lymphomas: Cutaneous Pseudolymphomas
Chapter 148	Langerhans Cell Histiocytosis
Chapter 149	Non–Langerhans Cell Histiocytosis
Chapter 150	Biology of Mast Cells and the Mastocytosis Syndromes
Section 26. Skin Manifestations of Internal Organ Disorders
Chapter 151	The Skin and Disorders of the Alimentary Tract, the Hepatobiliary System, Kidney, and Cardiopulmonary System
Chapter 152	Diabetes Mellitus and Other Endocrine Diseases
Chapter 153	Sarcoidosis
Chapter 154	Cutaneous Manifestations of Internal Malignant Disease: Cutaneous Paraneoplastic Syndromes
Section 27. The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders
Chapter 155	Mechanisms of Autoimmune Disease
Chapter 156	Lupus Erythematosus
Chapter 157	Dermatomyositis
Chapter 158	Scleroderma (Systemic Sclerosis)
Chapter 159	Scleredema and Scleromyxedema
Chapter 160	Relapsing Polychondritis
Chapter 161	Rheumatoid Arthritis, Rheumatic Fever, and Gout
Chapter 162	Sjögren Syndrome
Section 28.The Skin in Inflammatory and Other Vascular Disorders
Chapter 163	Endothelium in Inflammation and Angiogenesis
Chapter 164	Cutaneous Necrotizing Venulitis
Chapter 165	Systemic Necrotizing Vasculitis
Chapter 166	Erythema Elevatum Diutinum
Chapter 167	Adamantiades-Behçet Disease
Chapter 168	Kawasaki Syndrome
Chapter 169	Pigmented Purpuric Dermatoses
Chapter 170	Cryoglobulinemia and Cryofibrinogenemia
Chapter 171	Raynaud Phenomenon
Chapter 172	Malignant Atrophic Papulosis (Degos Disease)
Chapter 173	Vascular Malformations
Chapter 174	Cutaneous Changes in Peripheral Vascular Arterial Disease
Chapter 175	Cutaneous Changes in Venous and Lymphatic Insufficiency

Part 9. Disease Due to Microbial Agents, Infestations, Bites, and Stings

Section 29. Bacterial Disease
Chapter 176	General Considerations of Bacterial Diseases
Chapter 177	Superficial Cutaneous Infections and Pyodermas
Chapter 178	Gram-Positive Infections Associated with Toxin Production
Chapter 179	Soft-Tissue Infections: Erysipelas, Cellulitis, Gangrenous Cellulitis, and Myonecrosis
Chapter 180	Gram-Negative Coccal and Bacillary Infections
Chapter 181	The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation
Chapter 182	Bartonellosis
Chapter 183	Miscellaneous Bacterial Infections with Cutaneous Manifestations
Chapter 184	Tuberculosis and Infections with Atypical Mycobacteria
Chapter 185	Actinomycosis, Nocardiosis, and Actinomycetoma
Chapter 186	Leprosy
Chapter 187	Lyme Borreliosis
Section 30. Fungal Diseases
Chapter 188	Superficial Fungal Infection: Dermatophytosis, Onychomycosis, Tinea Nigra, Piedra
Chapter 189	Yeast Infections: Candidiasis and Tinea (Pityriasis) Versicolor
Chapter 190	Deep Fungal Infections
Section 31. Viral and Rickettsial Diseases
Chapter 191	Viral Diseases: General Considerations
Chapter 192	Exanthematous Viral Diseases
Chapter 193	Herpes Simplex
Chapter 194	Varicella and Herpes Zoster
Chapter 195	Poxvirus Infections
Chapter 196	Warts
Chapter 197	Human Retroviral Disease: Human T-Lymphotropic Viruses
Chapter 198	Cutaneous Manifestations of Human Immunodeficiency Virus Disease
Chapter 199	The Rickettsioses, Ehrlichioses, and Anaplasmoses
Section 32. Sexually Transmitted Diseases
Chapter 200	Syphilis
Chapter 201	Endemic (Non-Venereal) Treponematoses
Chapter 202	Chancroid
Chapter 203	Lymphogranuloma Venereum
Chapter 204	Granuloma Inguinale
Chapter 205	Gonorrhea and Other Venereal Diseases
Section 33. Infestations, Bites, and Stings
Chapter 206	Leishmaniasis and Other Protozoan Infections
Chapter 207	Helminthic Infections
Chapter 208	Scabies, Other Mites, and Pediculosis
Chapter 209	Bites and Stings of Terrestrial and Aquatic Life
Chapter 210	Arthropod Bites and Stings

Part 10. Occupational Skin Diseases and Skin Diseases Due to Biologic Warfare

Section 34. Occupational Skin Diseases
Chapter 211	Occupational Skin Diseases Due to Irritants and Allergens
Chapter 212	Occupational Noneczematous Skin Diseases Due to Biologic, Physical, and Chemical Agents
Section 35. The Skin in Bioterrorism and Biologic Warfare
Chapter 213	Cutaneous Manifestations of Biologic, Chemical, and Radiologic Terrorism Attacks

Part 11. Therapeutics

Section 36. Topical Therapy
Chapter 214	Principles of Topical Therapy
Chapter 215	Pharmacokinetics and Topical Applications of Drugs
Chapter 216	Topical Corticosteroids
Chapter 217	Topical Retinoids
Chapter 218	Topical Antibiotics
Chapter 219	Topical Antifungal Agents
Chapter 220	Topical and Intralesional Cytotoxic Agents
Chapter 221	Topical Immunomodulators
Chapter 222	Other Topical Medications
Chapter 223	Photoprotection and Sun Protective Agents
Chapter 224	Special Considerations for Topical Therapy of Ethnic Skin
Section 37. Systemic Therapy
Chapter 225	Systemic Glucocorticoids
Chapter 226	Dapsone
Chapter 227	Aminoquinolines
Chapter 228	Cytotoxic and Antimetabolic Agents
Chapter 229	Retinoids
Chapter 230	Antihistamines
Chapter 231	Antibiotics
Chapter 232	Antiviral Drugs
Chapter 233	Oral Antifungal Agents
Chapter 234	Immunosuppressive and Immunomodulatory Drugs
Chapter 235	Immunobiologicals, Cytokines, and Growth Factors in Dermatology
Chapter 236	Anti-Angiogenic Agents
Chapter 237	Drug Interactions
Section 38. Physical Treatments
Chapter 238	Therapeutic Photomedicine: Phototherapy
Chapter 239	Photochemotherapy and Photodynamic Therapy
Chapter 240	Lasers and Flashlamps in Dermatology
Chapter 241	Radiotherapy
Section 39. Complementary and Alternative Dermatology
Chapter 242	Complementary and Alternative Medicine in Dermatology
Section 40. Surgery in Dermatology
Chapter 243	Dermatologic Surgery: Introduction to Anatomy and Approach
Chapter 244	Excisional Surgery and Repair, Including Flaps and Grafts
Chapter 245	Mohs Micrographic Surgery
Chapter 246	Nail Surgery
Chapter 247	Cryosurgery and Electrosurgery
Chapter 248	Surgical Complications
Chapter 249	Wound Repair: Mechanisms and Practical Considerations
Chapter 250	Treatment for Varicose and Telangiectatic Leg Veins
Section 41. Cosmetic Dermatology
Chapter 251	Cosmetics and Skin Care in Dermatology
Chapter 252	Skin Resurfacing: Ablative Lasers, Chemical Peels, and Dermabrasion
Chapter 253	Cosmetic Applications of Non-Ablative Lasers and Other Light Devices
Chapter 254	Liposuction
Chapter 255	Soft-Tissue Augmentation
Chapter 256	Botulinum Toxin
Chapter 257	Hair Transplantation and Alopecia Reduction

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