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Williams Hematology, 8e

Marshall A. Lichtman, Thomas J. Kipps, Uri Seligsohn, Kenneth Kaushansky, Josef T. Prchal

Preface Copyright Contributors

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Part I. Clinical Evaluation of the Patient

Chapter 1	Initial Approach to the Patient: History and Physical Examination
Chapter 2	Examination of Blood Cells
Chapter 3	Examination of the Marrow

Part II. The Organization of the Lymphohematopoietic Tissues

Chapter 4	Structure of the Marrow and the Hematopoietic Microenvironment
Chapter 5	The Organization and Structure of Lymphoid Tissues

Part III. Epochal Hematology

Chapter 6	Hematology of the Fetus and Newborn
Chapter 7	Hematology during Pregnancy
Chapter 8	Hematology in Older Persons

Part IV. Molecular and Cellular Hematology

Chapter 9	Genetic Principles and Molecular Biology
Chapter 10	Genomics and Epigenetics
Chapter 11	Cytogenetics and Molecular Abnormalities
Chapter 12	Apoptosis
Chapter 13	Cell-Cycle Regulation and Hematologic Disorders
Chapter 14	Signal Transduction Pathways
Chapter 15	The Cluster of Differentiation Antigens
Chapter 16	Hematopoietic Stem Cells, Progenitors, and Cytokines
Chapter 17	The Inflammatory Response
Chapter 18	Innate Immunity
Chapter 19	Dendritic Cells and the Control of Innate and Adaptive Immunity

Part V. Therapeutic Principles

Chapter 20	Pharmacology and Toxicity of Antineoplastic Drugs
Chapter 21	Principles of Hematopoietic Cell Transplantation
Chapter 22	Treatment of Infections in the Immunocompromised Host
Chapter 23	Principles of Antithrombotic Therapy
Chapter 24	Principles of Immune Cell Therapy
Chapter 25	Principles of Vaccine Therapy
Chapter 26	Principles of Therapeutic Apheresis: Indications, Efficacy, and Complications
Chapter 27	Principles of Gene Transfer for Therapy
Chapter 28	Regenerative Medicine: Principles of Multipotential Cell Therapy for Tissue Replacement

Part VI. The Erythrocyte

Chapter 29	Morphology of the Erythron
Chapter 30	Composition of the Erythrocyte
Chapter 31	Production of Erythrocytes
Chapter 32	Destruction of Erythrocytes
Chapter 33	Clinical Manifestations and Classification of Erythrocyte Disorders
Chapter 34	Aplastic Anemia: Acquired and Inherited
Chapter 35	Pure Red Cell Aplasia
Chapter 36	Anemia of Chronic Renal Disease
Chapter 37	Anemia of Chronic Disease
Chapter 38	Anemia of Endocrine Disorders
Chapter 39	The Congenital Dyserythropoietic Anemias
Chapter 40	Paroxysmal Nocturnal Hemoglobinuria
Chapter 41	Folate, Cobalamin, and Megaloblastic Anemias
Chapter 42	Disorders of Iron Metabolism
Chapter 43	Anemia Resulting from Other Nutritional Deficiencies
Chapter 44	Anemia Associated with Marrow Infiltration
Chapter 45	The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases
Chapter 46	Disorders of Red Cells Resulting from Enzyme Abnormalities
Chapter 47	The Thalassemias: Disorders of Globin Synthesis
Chapter 48	Disorders of Hemoglobin Structure: Sickle Cell Anemia and Related Abnormalities
Chapter 49	Methemoglobinemia and Other Dyshemoglobinemias
Chapter 50	Hemolytic Anemia Resulting from Physical Injury to Red Cells
Chapter 51	Hemolytic Anemia Resulting from Chemical and Physical Agents
Chapter 52	Hemolytic Anemia Resulting from Infections with Microorganisms
Chapter 53	Hemolytic Anemia Resulting from Immune Injury
Chapter 54	Alloimmune Hemolytic Disease of the Fetus and Newborn
Chapter 55	Hypersplenism and Hyposplenism
Chapter 56	Primary and Secondary Polycythemias (Erythrocytosis)
Chapter 57	The Porphyrias
Chapter 58	Hereditary and Acquired Sideroblastic Anemias

Part VII. Neutrophils, Eosinophils, Basophils and Mast Cells

Chapter 59	Morphology of Neutrophils, Eosinophils, and Basophils
Chapter 60	Composition of Neutrophils
Chapter 61	Production, Distribution, and Fate of Neutrophils
Chapter 62	Eosinophils and Their Disorders
Chapter 63	Basophils and Mast Cells and Their Disorders
Chapter 64	Classification and Clinical Manifestations of Neutrophil Disorders
Chapter 65	Neutropenia and Neutrophilia
Chapter 66	Disorders of Neutrophil Function

Part VIII. Monocytes and Macrophages

Chapter 67	Morphology of Monocytes and Macrophages
Chapter 68	Biochemistry and Functions of Monocytes and Macrophages
Chapter 69	Production, Distribution, and Fate of Monocytes and Macrophages
Chapter 70	Classification and Clinical Manifestations of Disorders of Monocytes and Macrophages
Chapter 71	Monocytosis and Monocytopenia
Chapter 72	Inflammatory and Malignant Histiocytosis
Chapter 73	Lipid Storage Diseases

Part IX. Lymphocytes and Plasma Cells

Chapter 74	Morphology of Lymphocytes and Plasma Cells
Chapter 75	Composition and Biochemistry of Lymphocytes and Plasma Cells
Chapter 76	Lymphopoiesis
Chapter 77	Functions of B Lymphocytes and Plasma Cells in Immunoglobulin Production
Chapter 78	Functions of T Lymphocytes: T-Cell Receptors for Antigen
Chapter 79	Functions of Natural Killer Cells
Chapter 80	Classification and Clinical Manifestations of Lymphocyte and Plasma Cell Disorders
Chapter 81	Lymphocytosis and Lymphocytopenia
Chapter 82	Immunodeficiency Diseases
Chapter 83	Hematologic Manifestations of Acquired Immunodeficiency Syndrome
Chapter 84	Mononucleosis Syndromes

Part X. Neoplastic Myeloid Diseases

Chapter 85	Classification and Clinical Manifestations of the Clonal Myeloid Disorders
Chapter 86	Polycythemia Vera
Chapter 87	Essential Thrombocythemia
Chapter 88	Myelodysplastic Syndromes (Clonal Cytopenias and Oligoblastic Myelogenous Leukemia)
Chapter 89	Acute Myelogenous Leukemia
Chapter 90	Chronic Myelogenous Leukemia and Related Disorders
Chapter 91	Primary Myelofibrosis

Part XI. Neoplastic Lymphoid Diseases

Chapter 92	Classification of Malignant Lymphoid Disorders
Chapter 93	Acute Lymphoblastic Leukemia
Chapter 94	Chronic Lymphocytic Leukemia and Related Diseases
Chapter 95	Hairy Cell Leukemia
Chapter 96	Large Granular Lymphocytic Leukemia
Chapter 97	General Considerations of Lymphoma: Epidemiology, Etiology, Heterogeneity, and Primary Extranodal Disease
Chapter 98	Pathology of Malignant Lymphomas
Chapter 99	Hodgkin Lymphoma
Chapter 100	Diffuse Large B-Cell Lymphoma
Chapter 101	Follicular Lymphoma
Chapter 102	Mantle Cell Lymphoma
Chapter 103	Marginal Zone B-Cell Lymphomas
Chapter 104	Burkitt Lymphoma
Chapter 105	Cutaneous T-Cell Lymphoma (Mycosis Fungoides and Sézary Syndrome)
Chapter 106	Mature T-Cell and Natural Killer Cell Lymphomas
Chapter 107	Plasma Cell Neoplasms: General Considerations
Chapter 108	Essential Monoclonal Gammopathy
Chapter 109	Myeloma
Chapter 110	The Amyloidoses
Chapter 111	Macroglobulinemia
Chapter 112	Heavy-Chain Disease

Part XII. Hemostasis and Thrombosis

Chapter 113	Megakaryopoiesis and Thrombopoiesis
Chapter 114	Platelet Morphology, Biochemistry, and Function
Chapter 115	Molecular Biology and Biochemistry of the Coagulation Factors and Pathways of Hemostasis
Chapter 116	Control of Coagulation Reactions
Chapter 117	Vascular Function in Hemostasis
Chapter 118	Classification, Clinical Manifestations, and Evaluation of Disorders of Hemostasis
Chapter 119	Thrombocytopenia
Chapter 120	Reactive Thrombocytosis
Chapter 121	Hereditary Qualitative Platelet Disorders
Chapter 122	Acquired Qualitative Platelet Disorders
Chapter 123	The Vascular Purpuras
Chapter 124	Hemophilia A and Hemophilia B
Chapter 125	Inherited Deficiencies of Coagulation Factors II, V, VII, X, XI, and XIII and Combined Deficiencies of Factors V and VIII and of the Vitamin K-Dependent Factors
Chapter 126	Hereditary Fibrinogen Abnormalities
Chapter 127	von Willebrand Disease
Chapter 128	Antibody-Mediated Coagulation Factor Deficiencies
Chapter 129	Hemostatic Dysfunction Related to Liver Diseases and Liver Transplantation
Chapter 130	Disseminated Intravascular Coagulation
Chapter 131	Hereditary Thrombophilia
Chapter 132	The Antiphospholipid Syndrome
Chapter 133	Antibody-Mediated Thrombotic Disorders: Thrombotic Thrombocytopenic Purpura and Heparin-Induced Thrombocytopenia
Chapter 134	Venous Thrombosis
Chapter 135	Atherothrombosis: Disease Initiation, Progression, and Treatment
Chapter 136	Fibrinolysis and Thrombolysis

Part XIII. Transfusion Medicine

Chapter 137	Erythrocyte Antigens and Antibodies
Chapter 138	Human Leukocyte and Platelet Antigens
Chapter 139	Blood Procurement and Screening
Chapter 140	Red Cell Transfusion
Chapter 141	Preservation and Clinical Use of Platelets

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Lichtman's Atlas of Hematology
Marshall A. Lichtman, Jean A. Shafer, Raymond E. Felgar, Nancy Wang

Comprehensive, online-only atlas of hematological disorders

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