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Fitzpatrick's Dermatology in General Medicine, 8e

Lowell A. Goldsmith, Stephen I. Katz, Barbara A. Gilchrest, Amy S. Paller, David J. Leffell, Klaus Wolff


Preface     Copyright     Contributors

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 Part 1. Introduction
 Section 1. General Considerations
Chapter 1The Epidemiology and Burden of Skin Disease
Chapter 2Evidence-Based Dermatology
Chapter 3Global Health in Dermatology
Chapter 4Public Health in Dermatology

 Section 2. Approach to Dermatologic Diagnosis
Chapter 5Structure of Skin Lesions and Fundamentals of Clinical Diagnosis
Chapter 6Basic Pathologic Reactions of the Skin

 Section 3. Overview of Biology, Development, and Structure of Skin
Chapter 7Development and Structure of Skin
Chapter 8Genetics in Relation to the Skin
Chapter 9Racial Considerations: Skin of Color
 Part 2. Disorders Presenting in Skin and Mucous Membranes
 Section 4. Inflammatory Disorders Based on T-Cell Reactivity and Dysregulation
Chapter 10Innate and Adaptive Immunity in the Skin
Chapter 11Cytokines
Chapter 12Chemokines
Chapter 13Allergic Contact Dermatitis
Chapter 14Atopic Dermatitis (Atopic Eczema)
Chapter 15Nummular Eczema, Lichen Simplex Chronicus, and Prurigo Nodularis
Chapter 16Vesicular Palmoplantar Eczema
Chapter 17Autosensitization Dermatitis
Chapter 18Psoriasis
Chapter 19Psoriatic Arthritis
Chapter 20Reactive Arthritis
Chapter 21Pustular Eruptions of Palms and Soles
Chapter 22Seborrheic Dermatitis
Chapter 23Exfoliative Dermatitis
Chapter 24Pityriasis Rubra Pilaris
Chapter 25Parapsoriasis and Pityriasis Lichenoides
Chapter 26Lichen Planus
Chapter 27Lichen Nitidus
Chapter 28Graft-versus-Host Disease
Chapter 29Skin Disease in Acute and Chronic Immunosuppression

 Section 5. Inflammatory Diseases Based on Neutrophils and Eosinophils
Chapter 30Regulation of the Production and Activation of Neutrophils
Chapter 31Regulation of the Production and Activation of Eosinophils
Chapter 32Acute Febrile Neutrophilic Dermatosis (Sweet Syndrome)
Chapter 33Pyoderma Gangrenosum
Chapter 34Granuloma Faciale
Chapter 35Subcorneal Pustular Dermatosis (Sneddon–Wilkinson Disease)
Chapter 36Eosinophils in Cutaneous Diseases

 Section 6. Inflammatory Diseases Based on Abnormal Humoral Reactivity and Other Inflammatory Diseases
Chapter 37Humoral Immunity and Complement
Chapter 38Urticaria and Angioedema
Chapter 39Erythema Multiforme
Chapter 40Epidermal Necrolysis (Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis)
Chapter 41Cutaneous Reactions to Drugs
Chapter 42Pityriasis Rosea
Chapter 43Erythema Annulare Centrifugum and Other Figurate Erythemas
Chapter 44Granuloma Annulare

 Section 7. Disorders of Epidermal Differentiation and Keratinization
Chapter 45Epidermal Stem Cells
Chapter 46Epidermal Growth and Differentiation
Chapter 47Skin as an Organ of Protection
Chapter 48Irritant Contact Dermatitis
Chapter 49The Ichthyoses
Chapter 50Inherited Palmoplantar Keratodermas
Chapter 51Acantholytic Disorders of the Skin
Chapter 52Porokeratosis

 Section 8. Disorders of Epidermal and Dermal-Epidermal Adhesion and Vesicular and Bullous Disorders
Chapter 53Epidermal and Epidermal–Dermal Adhesion
Chapter 54Pemphigus
Chapter 55Paraneoplastic Pemphigus
Chapter 56Bullous Pemphigoid
Chapter 57Cicatricial Pemphigoid
Chapter 58Linear Immunoglobulin A Dermatosis and Chronic Bullous Disease of Childhood
Chapter 59Pemphigoid Gestationis (Herpes Gestationis)
Chapter 60Epidermolysis Bullosa Acquisita
Chapter 61Dermatitis Herpetiformis
Chapter 62Inherited Epidermolysis Bullosa

 Section 9. Disorders of the Dermal Connective Tissue
Chapter 63Collagens, Elastic Fibers, and Other Extracellular Matrix Proteins of the Dermis
Chapter 64Morphea
Chapter 65Lichen Sclerosus
Chapter 66Dermal Hypertrophies and Benign Fibroblastic/Myofibroblastic Tumors
Chapter 67Anetoderma and Other Atrophic Disorders of the Skin
Chapter 68Ainhum and Pseudoainhum
Chapter 69Acquired Perforating Disorders

 Section 10. Disorders of Subcutaneous Tissue
Chapter 70Panniculitis
Chapter 71Lipodystrophy

 Section 11. Disorders of Melanocytes
Chapter 72Biology of Melanocytes
Chapter 73Albinism and Other Genetic Disorders of Pigmentation
Chapter 74Vitiligo
Chapter 75Hypomelanoses and Hypermelanoses

 Section 12. Disorders of the Oral and Genital Integument
Chapter 76Biology and Pathology of the Oral Cavity
Chapter 77Diseases and Disorders of the Male Genitalia
Chapter 78Diseases and Disorders of the Female Genitalia
 Part 3. Disorders of the Skin Appendages
 Section 13. Disorders of the Sebaceous Glands
Chapter 79Biology of Sebaceous Glands
Chapter 80Acne Vulgaris and Acneiform Eruptions
Chapter 81Rosacea
Chapter 82Perioral Dermatitis

 Section 14. Disorders of the Eccrine and Apocrine Glands
Chapter 83Biology of Eccrine and Apocrine Glands
Chapter 84Disorders of the Eccrine Sweat Glands and Sweating
Chapter 85Disorders of the Apocrine Sweat Glands

 Section 15. Disorders of the Hair and Nails
Chapter 86Biology of Hair Follicles
Chapter 87Keratosis Pilaris and Other Inflammatory Follicular Keratotic Syndromes
Chapter 88Hair Growth Disorders
Chapter 89Biology of Nails and Nail Disorders
 Part 4. Disorders Due to the Environment
 Section 16. Disorders Due to Ultraviolet Radiation
Chapter 90Fundamentals of Cutaneous Photobiology and Photoimmunology
Chapter 91Abnormal Responses to Ultraviolet Radiation: Idiopathic, Probably Immunologic, and Photoexacerbated
Chapter 92Abnormal Responses to Ultraviolet Radiation: Photosensitivity Induced by Exogenous Agents

 Section 17. Skin Changes Due to Other Physical and Chemical Factors
Chapter 93Thermoregulation
Chapter 94Cold Injuries
Chapter 95Thermal Injuries
Chapter 96Skin Problems in Amputees
Chapter 97Skin Problems in Ostomates
Chapter 98Corns and Calluses
Chapter 99Sports Dermatology
Chapter 100Decubitus (Pressure) Ulcers
Chapter 101Body Art
 Part 5. Neurocutaneous and Psychocutaneous Aspects of Skin Disease
 Section 18. Neurocutaneous and Psychocutaneous Skin Disease
Chapter 102Neurobiology of the Skin
Chapter 103Pathophysiology and Clinical Aspects of Pruritus
Chapter 104Psychocutaneous Skin Disease
Chapter 105Cutaneous Manifestations of Drug Abuse
Chapter 106Skin Signs of Physical Abuse
 Part 6. Skin Changes across the Span of Life
 Section 19. From Birth to Old Age
Chapter 107Neonatal, Pediatric, and Adolescent Dermatology
Chapter 108Skin Changes and Diseases in Pregnancy
Chapter 109Aging of Skin
 Part 7. Neoplasia
 Section 20. Carcinogenesis
Chapter 110Genome Instability, DNA Repair, and Cancer
Chapter 111Chemical Carcinogenesis
Chapter 112Ultraviolet Radiation Carcinogenesis

 Section 21. Epidermal and Appendageal Tumors
Chapter 113Epithelial Precancerous Lesions
Chapter 114Squamous Cell Carcinoma
Chapter 115Basal Cell Carcinoma
Chapter 116Basal Cell Nevus Syndrome
Chapter 117Keratoacanthoma
Chapter 118Benign Epithelial Tumors, Hamartomas, and Hyperplasias
Chapter 119Appendage Tumors and Hamartomas of the Skin
Chapter 120Merkel Cell Carcinoma
Chapter 121Mammary and Extramammary Paget's Disease

 Section 22. Melanocytic Tumors
Chapter 122Benign Neoplasias and Hyperplasias of Melanocytes
Chapter 123Atypical (Dysplastic) Melanocytic Nevi
Chapter 124Cutaneous Melanoma

 Section 23. Tumors and Hyperplasias of the Dermis and Subcutaneous Fat
Chapter 125Malignant Fibrous, Fibrohistiocytic, and Histiocytic Tumors of the Dermis
Chapter 126Vascular Tumors
Chapter 127Neoplasias and Hyperplasias of Muscular and Neural Origin
Chapter 128Kaposi's Sarcoma and Angiosarcoma
Chapter 129Neoplasms of Subcutaneous Fat
 Part 8. The Skin in Systemic Disease
 Section 24. Skin in Nutritional, Metabolic, and Heritable Disease
Chapter 130Cutaneous Changes in Nutritional Disease
Chapter 131Cutaneous Changes in Errors of Amino Acid Metabolism
Chapter 132The Porphyrias
Chapter 133Amyloidosis of the Skin
Chapter 134Systemic Autoinflammatory Diseases
Chapter 135Xanthomatoses and Lipoprotein Disorders
Chapter 136Fabry Disease
Chapter 137Lipoid Proteinosis and Heritable Disorders of Connective Tissue
Chapter 138Cutaneous Mineralization and Ossification
Chapter 139Hereditary Disorders of Genome Instability and DNA Repair
Chapter 140Tuberous Sclerosis Complex
Chapter 141The Neurofibromatoses
Chapter 142Ectodermal Dysplasias
Chapter 143Genetic Immunodeficiency Diseases

 Section 25. Skin Manifestations of Bone Marrow or Blood Chemistry Disorders
Chapter 144Hematologic Diseases
Chapter 145Cutaneous Lymphoma
Chapter 146Inflammatory Diseases that Simulate Lymphomas: Cutaneous Pseudolymphomas
Chapter 147Cutaneous Langerhans Cell Histiocytosis
Chapter 148Non-Langerhans Cell Histiocytosis
Chapter 149Mastocytosis

 Section 26. Skin Manifestations of Internal Organ Disorders
Chapter 150The Skin and Disorders of the Alimentary Tract, the Hepatobiliary System, the Kidney, and the Cardiopulmonary System
Chapter 151Diabetes Mellitus and Other Endocrine Diseases
Chapter 152Sarcoidosis
Chapter 153Cutaneous Manifestations of Internal Malignant Disease: Cutaneous Paraneoplastic Syndromes

 Section 27. The Skin in Vascular and Connective Tissue and Other Autoimmune Disorders
Chapter 154Mechanisms of Autoimmune Disease
Chapter 155Lupus Erythematosus
Chapter 156Dermatomyositis
Chapter 157Scleroderma
Chapter 158Scleredema and Scleromyxedema
Chapter 159Relapsing Polychondritis
Chapter 160Rheumatoid Arthritis, Rheumatic Fever, and Gout
Chapter 161Sjögren's Syndrome

 Section 28.The Skin in Inflammatory and Other Vascular Disorders
Chapter 162Endothelium in Inflammation and Angiogenesis
Chapter 163Cutaneous Necrotizing Venulitis
Chapter 164Systemic Necrotizing Arteritis
Chapter 165Erythema Elevatum Diutinum
Chapter 166Adamantiades–Behçet Disease
Chapter 167Kawasaki Disease
Chapter 168Pigmented Purpuric Dermatoses
Chapter 169Cryoglobulinemia and Cryofibrinogenemia
Chapter 170Raynaud Phenomenon
Chapter 171Malignant Atrophic Papulosis (Degos Disease)
Chapter 172Vascular Malformations
Chapter 173Cutaneous Changes in Peripheral Arterial Vascular Disease
Chapter 174Cutaneous Changes in Peripheral Venous and Lymphatic Insufficiency
 Part 9. Disease Due to Microbial Agents, Infestations, Bites, and Stings
 Section 29. Bacterial Disease
Chapter 175General Considerations of Bacterial Diseases
Chapter 176Superficial Cutaneous Infections and Pyodermas
Chapter 177Gram-Positive Infections Associated with Toxin Production
Chapter 178Non-Necrotizing Infections of the Dermis and Subcutaneous Fat: Cellulitis and Erysipelas
Chapter 179Necrotizing Soft Tissue Infections: Necrotizing Fasciitis, Gangrenous Cellulitis, and Myonecrosis
Chapter 180Gram-Negative Coccal and Bacillary Infections
Chapter 181The Skin in Infective Endocarditis, Sepsis, Septic Shock, and Disseminated Intravascular Coagulation
Chapter 182Bartonellosis
Chapter 183Miscellaneous Bacterial Infections with Cutaneous Manifestations
Chapter 184Tuberculosis and Infections with Atypical Mycobacteria
Chapter 185Actinomycosis, Nocardiosis, and Actinomycetoma
Chapter 186Leprosy
Chapter 187Lyme Borreliosis

 Section 30. Fungal Diseases
Chapter 188Superficial Fungal Infection
Chapter 189Yeast Infections: Candidiasis, Tinea (Pityriasis) Versicolor, and Malassezia (Pityrosporum) Folliculitis
Chapter 190Deep Fungal Infections

 Section 31. Viral and Rickettsial Diseases
Chapter 191General Considerations of Viral Diseases
Chapter 192Exanthematous Viral Diseases
Chapter 193Herpes Simplex
Chapter 194Varicella and Herpes Zoster
Chapter 195Poxvirus Infections
Chapter 196Human Papilloma Virus Infections
Chapter 197Human T-Lymphotropic Viruses
Chapter 198Cutaneous Manifestations of Human Immunodeficiency Virus Disease
Chapter 199The Rickettsioses, Ehrlichioses, and Anaplasmoses

 Section 32. Sexually Transmitted Diseases
Chapter 200Syphilis
Chapter 201Endemic (Nonvenereal) Treponematoses
Chapter 202Chancroid
Chapter 203Lymphogranuloma Venereum
Chapter 204Granuloma Inguinale
Chapter 205Gonorrhea, Mycoplasma, and Vaginosis

 Section 33. Infestations, Bites, and Stings
Chapter 206Leishmaniasis and Other Protozoan Infections
Chapter 207Helminthic Infections
Chapter 208Scabies, Other Mites, and Pediculosis
Chapter 209Bites and Stings of Terrestrial and Aquatic Life
Chapter 210Arthropod Bites and Stings
 Part 10. Occupational Skin Diseases and Skin Diseases Due to Biologic Warfare
 Section 34. Occupational Skin Diseases
Chapter 211Occupational Skin Diseases Due to Irritants and Allergens
Chapter 212Occupational Noneczematous Skin Diseases Due to Biologic, Physical, and Chemical Agents: Introduction

 Section 35. The Skin in Bioterrorism and Biologic Warfare
Chapter 213Cutaneous Manifestations of Biologic, Chemical, and Radiologic Attacks
 Part 11. Therapeutics
 Section 36. Topical Therapy
Chapter 214Principles of Topical Therapy
Chapter 215Pharmacokinetics and Topical Applications of Drugs
Chapter 216Topical Corticosteroids
Chapter 217Topical Retinoids
Chapter 218Topical Antibiotics
Chapter 219Topical Antifungal Agents
Chapter 220Topical and Intralesional Cytotoxic Agents
Chapter 221Topical Immunomodulators
Chapter 222Other Topical Medications
Chapter 223Photoprotection

 Section 37. Systemic Therapy
Chapter 224Systemic Glucocorticoids
Chapter 225Dapsone
Chapter 226Aminoquinolines
Chapter 227Cytotoxic and Antimetabolic Agents
Chapter 228Retinoids
Chapter 229Antihistamines
Chapter 230Antibiotics
Chapter 231Antiviral Drugs
Chapter 232Oral Antifungal Agents
Chapter 233Immunosuppressive and Immunomodulatory Drugs
Chapter 234Immunobiologicals, Cytokines, and Growth Factors in Dermatology
Chapter 235Antiangiogenic Agents
Chapter 236Drug Interactions

 Section 38. Physical Treatments
Chapter 237Phototherapy
Chapter 238Photochemotherapy and Photodynamic Therapy
Chapter 239Lasers and Flashlamps in Dermatology
Chapter 240Radiotherapy

 Section 39. Complementary and Alternative Dermatology
Chapter 241Complementary and Alternative Medicine in Dermatology

 Section 40. Surgery in Dermatology
Chapter 242Anatomy and Approach in Dermatologic Surgery
Chapter 243Excisional Surgery and Repair, Flaps, and Grafts
Chapter 244Mohs Micrographic Surgery
Chapter 245Nail Surgery
Chapter 246Cryosurgery and Electrosurgery
Chapter 247Surgical Complications
Chapter 248Mechanisms of Wound Repair, Wound Healing, and Wound Dressing
Chapter 249Treatment for Varicose and Telangiectatic Leg Veins

 Section 41. Cosmetic Dermatology
Chapter 250Cosmetics and Skin Care in Dermatology
Chapter 251Ablative Lasers, Chemical Peels, and Dermabrasion
Chapter 252Cosmetic Applications of Nonablative Lasers and Other Light Devices
Chapter 253Liposuction
Chapter 254Soft Tissue Augmentation
Chapter 255Botulinum Toxin
Chapter 256Hair Transplantation and Alopecia Reduction


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